99 Top Hematology Dissertation Topics for 2026

Hematological Disorders and Diagnostics

• Investigating the Integration of Artificial Intelligence in Enhancing Diagnostic Accuracy for Rare Myeloid and Lymphoid Malignancies.
• Analyzing the Genetic Basis of Inherited Bleeding Disorders Using Advanced Whole-Exome Sequencing and Functional Genomics Approaches.
• Assessing the Role of Platelet Function Testing in Personalized Antiplatelet Therapy for High-Risk Cardiovascular and Cerebrovascular Patients.
• Assessing the Hematological Consequences of Dose-Dense Chemotherapy Protocols in Patients with Advanced Stage Solid Organ Malignancies.
• Exploring Patient-Reported Outcome Measures to Improve the Quality of Life for Adults Living with Sickle Cell Disease.
• Reviewing the Recent Advancements in Adeno-Associated Virus Vector-Based Gene Therapy for the Permanent Treatment of Hemophilia.
• Evaluating the Clinical Efficacy of CRISPR-Cas9 Gene Editing Techniques in Treating Severe Beta-Thalassemia and Other Major Hemoglobinopathies.
• Investigating the Impact of Epigenetic Dysregulation and DNA Methylation Patterns on the Progression of Hematological Malignancies.
• Exploring the Use of Machine Learning Algorithms in Predicting Clinical Bleeding Risk in Patients with Undiagnosed Coagulopathies.
• Evaluating the Long-Term Efficacy of Targeted Tyrosine Kinase Inhibitors for Treating Refractory Leukemia in Pediatric Populations.
• Investigating the Effectiveness of the UK’s National Screening Programs for Newborns at Risk of Major Hematological Disorders.
• Assessing the Hematological Consequences of Normothermic Machine Perfusion and Other Organ Preservation Techniques in Clinical Transplantation.
• Exploring the Longitudinal Hematological Changes During High-Risk Pregnancies and Their Correlation with Adverse Neonatal Clinical Outcomes.
• Examining the Diagnostic Utility of Novel Molecular Markers for Thrombophilia in Pregnant Women with Recurrent Pregnancy Loss.
• Evaluating the Impact of High-Intensity Interval Training on Erythropoiesis and Red Blood Cell Rheology in Elite Athletes.
• Examining the Use of Liquid Biopsy and Circulating Tumor DNA in Diagnosing Minimal Residual Disease in Hematology.
• Examining the Clinical Efficacy of Prophylactic Platelet Transfusions in Critically Ill Patients Within Intensive Care Settings.
• Analyzing the Post-Pandemic Trends of Blood Donation Patterns and Transfusion Service Sustainability in the UK Healthcare System.

Hemostasis and Coagulation

• The Intersection of Hematology and Geriatrics: Addressing Management Challenges of Age-Related Anemia and Polypharmacy-Induced Bleeding in the Elderly.
• Analyzing the Impact of Clonal Hematopoiesis on the Progression and Cardiovascular Complications of Chronic Hematological Diseases.
• Exploring the Shifting Prevalence of Diverse Hemoglobinopathies Within the Multi-Ethnic UK Population Through Genomic Surveillance.
• Examining the Use of Allogeneic and Base-Edited Chimeric Antigen Receptor (CAR) T-cell Therapy in Advanced Leukemia.
• Evaluating the Effectiveness of Haploidentical Stem Cell Transplantation Compared to Matched Unrelated Donors in Blood Disorders.
• Examining the Role of Procoagulant Extracellular Vesicles in Promoting Cancer Metastasis and Tumor-Associated Venous Thromboembolism.
• Analyzing the Diagnostic Value of Neutrophil-to-Lymphocyte Ratios as Early Hematological Markers of Sepsis-Induced Coagulopathy.
• Reviewing the Clinical Challenges and Successes in the Global Management of Transfusion-Dependent Thalassemia in the 2020s.
• Assessing the Role of Hypofibrinolysis in the Development and Recurrence of Unprovoked Venous Thromboembolism.
• Examining the Hematological Complications and Bone Marrow Microenvironment Changes in Patients with Myeloproliferative Neoplasms.
• Evaluating the Role of Selective CXCR4 Antagonists in Optimizing Stem Cell Mobilization for Hematopoietic Recovery.
• Analyzing the Advancements in Digital Morphometry and Automated Cell Image Analysis for Early Detection of Blood Disorders.
• Investigating the Genetic Polymorphisms and Pharmacogenomics Influencing Precision Warfarin and DOAC Dosing in High-Risk Hematology Patients.
• Investigating the Pathophysiological Link Between Hematology Parameters and the Development of Autoimmune Thyroiditis and Related Conditions.
• Evaluating the Hematological Manifestations and Risk of Thromboembolic Events in Patients with Systemic Small-Vessel Vasculitis.
• Evaluating the Role of Hypoxia-Inducible Factors in the Regulation of Iron Homeostasis and Erythroid Progenitor Differentiation.
• Evaluating the Hematological Aspects of Rare Iron Metabolism Disorders Including Ferroportin Disease and Hereditary Iron Refractory Anemia.
• Investigating the Efficacy of Novel Small Molecule Inhibitors in Targeting Intracellular Signaling Pathways of Hematological Cancers.
• Assessing the Role of Neonatal Platelet Function and Immature Platelet Fraction in Diagnosing Early-Onset Neonatal Thrombocytopenia.

Clinical Applications and Therapeutics

• Evaluating the Regulatory Role of the Bone Marrow Niche in Megakaryocyte Maturation and Efficient Platelet Production.
• Investigating the Therapeutic Potential of Hepcidin Antagonists in Managing Iron Redistribution and Anemia of Chronic Disease.
• Examining the Role of Contact System Activation and Factor XI Inhibitors in Preventing Thrombotic Disorders Without Bleeding.
• Evaluating the Use of Lentiviral Vector-Mediated Gene Therapy for the Long-Term Treatment of Transfusion-Dependent Beta-Thalassemia.
• Investigating the Use of Bispecific T-cell Engagers (BiTEs) as a Bridge to Transplant in Hematological Malignancies.
• Hematology in Orthopedics: An Exploration of Perioperative Hemostatic Management and Blood Conservation Strategies in Major Joint Replacement Surgery.
• Investigating the Incidence and Management of Post-Transplant Lymphoproliferative Disorders Following Solid Organ and Stem Cell Transplantation.
• Assessing the Hematological Profile and Erythropoietin Resistance Patterns in Patients with End-Stage Chronic Kidney Disease.
• Evaluating the Safety and Efficacy of Factor XIa Inhibitors for Stroke Prevention in Patients with Atrial Fibrillation.
• Assessing the Impact of Donor-Derived Clonal Hematopoiesis on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation.
• Evaluating the Use of Biosimilar Hematopoietic Growth Factors in Reducing Febrile Neutropenia Episodes During Aggressive Cancer Therapy.
• Investigating the Impact of Targeted Nutritional Interventions on Iron Stores and Hemoglobin Levels in High-Risk Populations.
• Investigating the Effectiveness of Extended-Duration Anticoagulant Therapy in Preventing Recurrent Venous Thromboembolism in High-Risk Patients.
• Investigating the Challenges of Equitable Access to Novel Orphan Drugs for Rare Blood Disorders in the UK.
• Analyzing the Clinical Utility of Soluble P-selectin as a Biomarker for Vaso-occlusive Crises in Sickle Cell Disease.
• Examining the Hematological Changes and Risk of Hepatocellular Carcinoma in Patients with Hereditary Hemochromatosis Type 1.
• Analyzing the Hematological Aspects of Complement-Mediated Hemolytic Uremic Syndrome and the Efficacy of Terminal Complement Inhibitors.
• Assessing the Long-Term Hematological Side Effects and Bleeding Risk Associated with Direct Oral Anticoagulant Use.

Systemic and Population Health

• Investigating the Spectrum of Hematological Manifestations and Bone Marrow Involvement in Systemic Autoimmune and Autoinflammatory Diseases.
• Analyzing the Impact of Plant-Based Diets and Lifestyle Factors on the Prevalence of Nutritional Anemias in Adolescents.
• Reviewing the Global Epidemiological Trends in the Incidence and Survival Rates of Pediatric Acute Lymphoblastic Leukemia.
• Assessing the Impact of Point-of-Care Viscoelastic Testing on Hemostatic Management and Outcomes in Severe Traumatic Injury.
• Examining the Regulatory Role of Exosomal MicroRNAs in Controlling Hematopoietic Stem Cell Differentiation and Leukemogenesis Processes.
• Evaluating the Hematological Aspects and Immunological Characteristics of Pure Red Cell Aplasia Associated with Thymoma.
• Hematology and Human Rights Law: Addressing Legal Barriers to Universal Access for Life-Saving Blood Products and Essential Gene Therapies.
• Analyzing the Physiological Mechanisms of Hypoxia-Induced Erythrocytosis and Red Blood Cell Adaptation in High-Altitude Populations.
• Investigating the Hematological Consequences of Microbiota Dysbiosis Following High-Dose Chemotherapy and Hematopoietic Stem Cell Transplantation.
• Examining the Prevalence and Risk Factors of Persistent Hematological Abnormalities in HIV-Infected Individuals Receiving Modern Antiretroviral Therapy.
• Assessing the Hematological Changes and Risk of Transformation Associated with Specific Cytogenetic Subsets of Myelodysplastic Syndromes.
• Investigating the Genetic Basis of Rare Hemoglobin Variants and Their Clinical Impact on Diverse Global Populations.
• Summarizing Recent Findings on the Molecular Genetics of Relapsed and Refractory Diffuse Large B-cell Lymphomas.
• Analyzing the Causal Association Between Elevated Hematological Inflammatory Markers and the Long-Term Risk of Cardiovascular Disease.
• Exploring the Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome in Enhancing Hematopoietic Recovery After Myeloablative Therapy.
• Assessing the Impact of NHS Integrated Care Systems on Improving Timely Access to Specialized Leukemia Treatments.
• Evaluating the Efficacy of Non-Invasive Hemoglobin Monitoring Technologies in Reducing Unnecessary Blood Sampling in Pediatric Wards.
• Evaluating the Role of Genetic Counseling in Improving Family Planning for Carriers of Hereditary Blood Disorders.

Emerging Research and Innovations

• Investigating the Impact of Labile Plasma Iron and Iron Overload on Multiorgan Damage in Transfusion-Dependent Patients.
• Assessing the Hematological Adaptation and Erythrocyte Morphological Changes in Astronauts During Long-Duration Space Exploration Missions.
• Analyzing the Incidence of Secondary Hematological Malignancies Following Treatment with Novel Targeted and Immunotherapeutic Agents.
• Assessing the Efficacy of Personalized Treatment Protocols for Follicular Lymphoma Within the UK’s Evolving Clinical Landscapes.
• Analyzing the Impact of Chronic Exposure to Environmental Microplastics on Hematopoietic Stem Cell Function and Longevity.
• Analyzing the Impact of Novel Selective Immunosuppressive Therapies on Reducing Graft-Versus-Host Disease in Stem Cell Transplantation.
• Analyzing the Role of Platelet-Derived Microvesicles in Driving Systemic Inflammation and Accelerated Atherosclerosis in Hematology.
• Evaluating the Current State of Bispecific Antibody Therapy as a Frontline Treatment for High-Risk Multiple Myeloma.
• Analyzing the Hematological Consequences of Portal Hypertension and Splenic Sequestration in Patients with Advanced Liver Cirrhosis.
• Evaluating the Accuracy and Clinical Impact of Point-of-Care Coagulation Testing in Managing Emergency Bleeding Disorders.
• Investigating the Long-Term Hematological Health of Children Born to Mothers with Pre-existing Chronic Myeloid Leukemia.
• Studying the Incidence and Multidisciplinary Management of Deep Vein Thrombosis in the UK’s Aging Population Groups.
• Assessing the Relationship Between Iron Deficiency Without Anemia and Impaired Cognitive Function in Elderly Patients.
• Evaluating the Impact of Virtual Reality Simulations in Hematology-Oncology Training for Enhancing Diagnostic Proficiency Among Fellows.
• Analyzing the Hematological Profile and Risk of Anemia of Inflammation in Patients with Early Rheumatoid Arthritis.
• Analyzing the Hematological Changes and Correlation with Disease Activity in Patients with Refractory Inflammatory Bowel Disease.
• Assessing the Genetic and Environmental Modifiers Influencing the Phenotypic Severity and Complications of Sickle Cell Disease.
• Examining the Relationship Between Ultra-Processed Food Consumption, Micronutrient Deficiencies, and Anemia Prevalence in the UK.
• Investigating the Role of Mitochondrial Dysfunction in Platelets as a Driver of Thrombocytopenia in Sepsis Patients.